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Professor Derek Stein, Associate Professor of Physics, Brown University
Title: "Single-Molecule Biophysics in Nanofluidic Structures"
Abstract: Microfluidic devices, from gene chips to cell sorters to portable glucose meters, are revolutionizing the way we perform biological and chemical analyses. As we shrink fluidic structures down further into the nanoscale, new physical phenomena emerge and present us with unique opportunities for studying single molecule biophysics. We also discover new ways to perform useful bioanalyses. I will describe a few lines of inquiry where fundamental science and technological possibilities converge. In particular, I will discuss the physics of confined polymers, how nanofluidic devices enable us to control the shape and motion of individual DNA molecules through their free energy landscape, and a new idea for measuring the sequence of a single biopolymer using mass spectrometry in combination with a nanoscale ion source.
Events are free and open to the public unless otherwise noted.