Rahul Sarpeshkar

Thomas E. Kurtz Professor
Professor of Physics
Professor of Engineering, Microbiology & Immunology, and Molecular & Systems Biology

Professor Sarpeshkar's interdisciplinary research uses analog circuits and analog computation as a universal language to design advanced quantum, bio-molecular, and nano-electronic circuits and systems, from atom to living cell. These systems are experimentally implemented in living synthetic microbial DNA-RNA-protein circuits in his wet lab, and in nano-electronic supercomputing chips that simulate biological and quantum computation in his dry lab. They also aid in the design of novel superconducting or NMR dynamical systems. Many common circuit themes in analog, physical, and biological computation include noise and thermodynamics, fault tolerance, feedback control, back action and loading, entanglement and correlation, precision measurement,  nonlinear dynamics, robustness-efficiency tradeoffs, scalability,  and hybrid quantum-classical operation. Professor Sarpeshkar recently filed four important patents on quantum computation with analog circuits and has just been elected to the National Academy of Inventors.

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Professor Sarpeshkar is Dartmouth's inaugural Thomas E. Kurtz Professor and Chair of the Neukom Computational Science Cluster. He is a Professor of Physics, Engineering, Microbiology & Immunology, and Physiology & Neurobiology.  His fundamental work has applications in quantum computation and circuit design,  medicine, biotechnology, bio-inspired and ultra-energy-efficient systems. He has published 137 research articles, holds 37 patents, and ​has authored a leading textbook on analog and bioelectronic computation. Prior to his joining Dartmouth, he was a tenured and award-winning professor at MIT.

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Education: 
BS, Electrical Engineering and Physics, MIT
PhD, Computation and Neural Systems, California Institute of Technology

Selected publications

R. Sarpeshkar, "Emulation of Quantum and Quantum-Inspired Dynamical Systems with Classical Transconductor-Capacitor Circuits", U.S. Patent App. 15826084, Filed Nov. 29th 2017. Provisional App.  62427776, Filed Nov. 29th. 2016. 

R. Sarpeshkar, "Emulation of Quantum and Quantum-Inspired Discrete-State Systems with Classical Transconductor-Capacitor Circuits", U.S. Patent Application No. 15826100, Filed Nov. 29th 2017. Provisional App. No. 62427776,  Filed Nov. 29th. 2016. 

R. Sarpeshkar, "Emulation of Quantum and Quantum-Inspired Spectrum Analysis and Superposition With Classical Transconductor-Capacitor Circuits", U.S. Patent Application No. 15826115, Filed Nov. 29th 2017. Provisional App. No. 62427776, Filed Nov. 29th. 2016.

R. Sarpeshkar, "A Quantum Cochlea for Efficient Spectrum Analysis", U.S. Divisional Patent Application No. 16/178,764, Filed Nov. 2nd 2018.

R. Daniel, J. R. Rubens, R. Sarpeshkar, and T. K. Lu, “Synthetic Analog Computation in Living Cells,” NATURE, Vol. 497:7451, pp. 619-623, 2013; doi:10.1038/nature12148

R. Sarpeshkar, “Analog Synthetic Biology,” Philosophical Transactions of the Royal Society A, 372: 20130110, 2014.

S.S. Woo, J. Kim, and R. Sarpeshkar, "A Digitally Programmable Cytomorphic Chip for Simulation of Arbitrary Biochemical Reaction Networks," IEEE Transactions on Biomedical Circuits and Systems, Vol. 12, No. 2, February 2018.

J. Kim, S.S. Woo, and R. Sarpeshkar, "Fast and Precise Emulation of Stochastic Biochemical Reaction Networks With Amplified Thermal Noise in Silicon Chips," IEEE Transactions on Biomedical Circuits and Systems, Vol. 12, No. 2, February 2018.

J. Zeng, J. Teo, A. Banerjee, T.W. Chapman, J. Kim, R. Sarpeshkar, “A Synthetic Microbial Operational Amplifier,” ACS Synth Biol. 2018 Sept 21; 7(9):2007-2013. Doi:10.1021/acssynbio.8b0013

J. Teo, S. Woo, and R. Sarpeshkar. “Synthetic Biology: A Unifying View and Review Using Analog Circuits,” IEEE Transactions on Biomedical Circuits and Systems, Special Issue in Synthetic Biology, Vol. 9, No. 4, August 2015.

S. Woo and R. Sarpeshkar, “A Cytomorphic Chip for Quantitative Modeling of Fundamental Bio-molecular Circuits,” IEEE Transactions on Biomedical Circuits and Systems, Special Issue in Synthetic Biology, Vol. 9, No. 4, August 2015.

S. S. Woo and R. Sarpeshkar, “A Spiking-Neuron Collective Analog Adder with Scalable Precision,” Proceedings of the IEEE International Symposium on Circuits and Systems (ISCAS), pp. 1620-1623, Beijing, China, May 2013.

S. Mandal and R. Sarpeshkar, “A Simple Model for the Thermal Noise of Saturated MOSFETs at All Inversion Levels," IEEE Journal of the Electron Devices Society, Vol. 5, No. 6, pp. 458–465, Nov. 2017. 

Benjamin I. Rapoport, Jakub T. Kedzierski, Rahul Sarpeshkar, “A Glucose Fuel Cell for Implantable Brain-Machine Interfaces,” PLoS ONE, Vol. 7, No. 6, e384386, 2012.

R. Sarpeshkar, “Ultra Low Power Bio-medical and Bio-inspired Systems,” in Frontiers of Engineering: Reports on Leading-Edge Engineering from the 2011 Symposium, pp. 137-144, National Academy of Engineering, National Academies Press, 2012.

R. Sarpeshkar, “Universal Principles for Ultra Low Power and Energy Efficient Design,” IEEE Transactions on Circuits and Systems-II, Special Issue on Ultra-Low-Power Electronics, Vol. 59, No. 4, pp. 193-198, 2012.

S.K. Arfin and R. Sarpeshkar, “An Energy-Efficient, Adiabatic Electrode Stimulator with Inductive Energy Recycling and Feedback Current Regulation,” IEEE Transactions on Biomedical Circuits and Systems, Vol. 6, No. 1, pp. 1-14, 2012.

R. Danial, S. S. Woo, L. Turicchia, and R. Sarpeshkar, “Analog Transistor Models of Bacterial Genetic Circuits,” Proceedings of the 2011 IEEE Biological Circuits and Systems (BioCAS) Conference, pp. 333-336, San Diego, CA, November 2011.

K. H. Wee, L. Turicchia and R. Sarpeshkar, “An Articulatory Silicon Vocal Tract for Speech and Hearing Prostheses,” IEEE Transactions on Biomedical Circuits and Systems, Vol. 5, No. 4, pp. 339-346, 2011. doi:10.1109/TBCAS.2011.2159858

W. Wattanapanitch and R. Sarpeshkar, “A low-power 32-channel digitally-programmable neural recording system,” IEEE Transaction on Biomedical Circuits and Systems, Vol. 5, No. 6, pp. 592-602, 2011.

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BOOKS

Ultra Low Power Bioelectronics: Fundamentals, Biomedical Applications, and Bio-inspired Systems, Rahul Sarpeshkar,  Cambridge University Press, 2010

 

AWARDS

Fellow, National Academy of Inventors

Fellow, IEEE

NSF CAREER Award

ONR Young Investigator Award

Packard Fellow Award

Junior Bose Teaching Award, MIT

 

NEWS

Award-Winning Scientist to Be First Faculty Cluster Chair,   Dartmouth Now,   July 7, 2015